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Knowledge Synthesis

Contributor: Jacqueline Kreller-Vanderkooy

1. Assemble a team and establish a timeline

  • Assemble a knowledge synthesis team consisting of a content expert and a minimum of two reviewers to reduce bias.
  • Establish a timeline so that all team members understand the time commitment, as knowledge syntheses can take a significant amount of time (often over a year).

Resources

2. Formulate the research question, choose a review type, and develop eligibility criteria

  • Formulate a clearly defined research question that has not been answered by an existing, current review.
  • You should have a draft research question before you choose the type of knowledge synthesis that you will conduct, as the type of research question you are asking should guide your choice of knowledge synthesis type.
  • Eligibility (also known as inclusion)  criteria define the characteristics of studies and publications to be included in the review. It is sometimes also necessary, for clarity, to define exclusion criteria that describe characteristics that included studies and publications should not have.

Resources for identifying the research question

Resources for choosing a review type

Resources for developing eligibility criteria

3. Develop the protocol

  • Develop, write, register, and make public a protocol outlining your plan for your knowledge synthesis.

Resources for protocol development

Places to register protocols

Options for publishing or otherwise making protocols public

  • Upload the protocol to the corresponding PROSPERO or OSF registration record
  • Deposit the protocol in an institutional repository, such as the University of Guelph’s Atrium
  • Publish your protocol in a journal that publishes protocols, such as BMC Systematic Reviews

4. Search for studies

  • Develop and document a systematic, comprehensive, and reproductible search strategy to find literature relevant to your question
  • Supplement your search with grey literature, citation mining (also known as citation chasing or cited reference searching), and hand searching

Resources for search strategy development and documentation

5. Select studies for inclusion

  • Remove duplicate studies from the entire pool of literature gathered
  • Complete two rounds of screening:
    • First, scan the titles and abstracts of all literature and exclude literature based on eligibility (inclusion) criteria
    • Second, screen the full-text of the remaining literature and exclude literature based on eligibility (inclusion) criteria

Resources for selecting studies

6. Critically appraise studies and identify the risk of bias

  • Assess the risk of bias and methodological quality of the studies.
  • Not all knowledge syntheses require critical appraisal or risk of bias assessment.

Resources for critically appraising studies and identifying the risk of bias

7. Extract and synthesize the data

  • Extract the data from the studies using a standardized extraction and coding form.
  • Combine and summarize the data using a table.
  • Synthesize the results through qualitative and/or quantitative synthesis (which may include meta-analysis)

Resources for extracting the data

Resources for synthesizing the data

8. Write the review

  • Write the review, being sure to follow all relevant reporting guidelines.

Resources for writing the review

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